Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer

Table 1 Logistic regression analysis of genotype frequencies of single nucleotide polymorphisms rs11614913, rs895819 and rs2910164 in colorectal cancer cases and controls in the Czech population

		Control		CRC
		n	%	n	%	OR1	95% Cl	Pvalue
	A/A	93	43.87	88	44.67	1		0.996a
miR-27a	A/G	94	44.34	86	43.65	0.98	(0.64-1.49)	0.950
	G/G	25	11.79	23	11.68	1.04	(0.54-1.98)	0.970
	AG + GG vs AA					1.01	(0.68-1.51)	0.954
	[G] vs [A]					0.999	(0.71-1.39)	0.995
	Trend	212		197		0.99	(0.8-1.22)	0.9118a
miR-146a	G/G	124	58.49	115	58.38	1		0.761a
	C/G	79	37.26	70	35.53	0.93	(0.61-1.41)	0.740
	C/C	9	4.25	12	6.09	1.31	(0.52-3.27)	0.556
	CG + CC vs GG					1.03	(0.69-1.54)	0.879
	[C] vs [G]					1.37	(0.56-3.33)	0.494
	Trend	212		197		0.97	(0.79-1.19)	0.7558a
miR-196-a2	C/C	87	41.04	82	41.62	1		0.6098a
	C/T	103	48.58	89	45.18	0.95	(0.62-1.45)	0.794
	T/T	22	10.38	26	13.2	1.32	(0.69-2.54)	0.415
	CT + TT vs CC					1.01	(0.68-1.51)	0.951
	[T] vs [C]					1.04	(0.75-1.45)	0.811
	Trend	212		197		1.08	(0.8-1.46)	0.5987a

P-values are calculated according to Wald’s test.

^aP-values according to likelihood ratio-test;

¹Age and sex adjusted; CRC: Colorectal cancer; OR: Odds ratio; CI: Confidence interval.