Patatin-like phospholipase domain containing-3 gene I148M polymorphism, steatosis, and liver damage in hereditary hemochromatosis

Table 2 Independent predictors of steatosis and cirrhosis in Italian patients with homozygous for the C282Y HFE mutation of hereditary hemochromatosis, as evaluated by logistic regression analysis

	OR	95% CI	Pvalue
Independent predictors of steatosis n = 123
BMI (per kg/m2)	1.22	1.06-1.42	0.008
ALT (per IU/mL)	1.01	0.99-1.02	0.353
PNPLA3 genotype (per p allele)	1.84	1.05-3.31	0.037
Independent predictors of cirrhosis n = 174
Ferritin (ng/mL)	1.001	1.000-1.002	< 0.0001
Diabetes	0.54	0.26-1.16	0.101
BMI (>/m2)	1.83	1.02-3.57	0.055
PNPLA3 p allele present (BMI > 25)	0.76	0.37-1.53	0.453
PNPLA3 p allele present (BMI ≤ 25)	3.26	1.28-10.30	0.024

OR: Odds ratio; CI: Confidence interval; BMI: Body mass index; ALT: Alanine aminotransaminase; p.148M: PNPLA3 rs738409 148Met protein variant.