Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk

Table 3 Predictive potential of adiponectin and soluble vascular cell adhesion molecule-1 regarding colorectal cancer risk: Relative integrated discrimination improvement and improvement of area under the curve

	AUC	Pvalue for AUCimprovement	RIDI (%)	95% CI
Multivariate model1	0.89
+ Adiponectin	0.98	0.009	12.2	10.9-13.6
+ sVCAM-1	0.92	0.09	9.9	8.7-11.0
+ Adiponectin + sVCAM-1	0.98	0.01	26.5	24.4-28.7

¹Multivariate model was adjusted for age, sex, BMI, intervention group, alcohol intake, physical activity, smoking status, family history of colorectal cancer, waist circumference, height and educational level. Models including adiponectin and/or sVCAM-1 were compared to the multivariate model. n = 50 colorectal cancer cases and 100 controls. BMI: Body mass index; RIDI: Relative integrated discrimination improvement; AUC: Area under the receiver operating curve; sVCAM-1: Soluble vascular cell adhesion molecule-1; CI: Confidence interval.