Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk

Table 1 Baseline characteristics of colorectal cancer cases and controls

	Cases (n= 50)		Controls (n= 100)		Pvalue1
Age, yr	51.8	± 5.6	52.1	± 5.6	0.8
Gender					1.0
Men	28	56.0%	56	56.0%
Women	22	44.0%	44	44.0%
Intervention group					1.0
Yes	27	54.0%	54	54.0%
No (placebo)	23	46.0%	46	46.0%
BMI, kg/m²					1.0
< 25	24	48.0%	48	48.0%
≥ 25	26	52.0%	52	52.0%
Waist circumference, cm	88.2	± 12.9	82.2	± 12.1	0.01
Height, cm	169.3	± 7.1	167.8	± 8.5	0.3
Smoking status					0.9
Never smoker	23	46.0%	46	46.0%
Former smoker	21	42.0%	40	40.0%
Current smoker	6	12.0%	14	14.0%
Alcohol intake, g/d	24	± 24.4	15.4	± 16.3	0.01
Physical activity					0.4
Low	10	20.0%	26	26.0%
Moderate	18	36.0%	25	25.0%
High	22	44.0%	49	49.0%
Educational level, yr					0.9
< 12	30	60.0%	61	61.0%
≥ 12	20	40.0%	39	39.0%
Family history of colorectal cancer2
No	45	90.0%	84	84.0%	0.3
Yes	5	10.0%	16	16.0%
Plasma levels of biomarkers
Adiponectin, µg/mL	9.0	± 4.7	10.9	± 7.5	0.2
Leptin, ng/mL	8.5	± 5.3	8.6	± 8.7	0.5
sVCAM-1, ng/mL	750.3	± 316.2	677.6	± 215.3	0.2
sICAM-1, ng/mL	249.7	± 80.3	247.8	± 67.3	0.9
sE-selectin, ng/mL	41.1	± 16.9	39.3	± 16.0	0.7
MCP-1, pg/mL	268.2	± 117.4	249	± 78.2	0.3
hs-CRP, mg/L	2.4	± 4.5	2.2	± 4.4	0.3

¹P value for the comparison of cases and controls by Student t test or χ² test, as appropriate. Biomarker variables were log-transformed to improve normality. Values are mean ± SD or n % as appropriate.

²In first degree relatives. BMI: Body mass index; hs-CRP: Highly sensitive C-reactive protein; sICAM-1: Soluble intercellular adhesion molecule-1; sVCAM-1: Soluble vascular cell adhesion molecule-1; sE-selectin: Soluble E-selectin; MCP-1: Monocyte chemoattractant protein-1.