Globulin-platelet model predicts minimal fibrosis and cirrhosis in chronic hepatitis B virus infected patients

Table 5 Validity of age-platelet count ratio, aspartate aminotransferase-platelet ratio, age-aspartate aminotransferase model, fibrosis index, FIB-4, and fibrosis-cirrhosis index for prediction of cirrhosis (F4) and comparison with globulin/platelet model

Fibrosis test	Cutoff value	Specificity %	Sensitivity %	PPV %	NPV %	AUC (95% CI)	Standard error	P value(vs GP model)
FI	2.16	53.4	81.8	15.8	96.4	0.717 (0.569-0.865)	0.075	> 0.05
APRI	0.77	72.8	72.7	22.2	96.1	0.703 (0.584-0.822)	0.061	> 0.05
FIB-4	2.29	89.3	72.7	42.0	96.8	0.768 (0.050-0.931)	0.083	> 0.05
FCI	0.10	68.0	81.8	21.4	97.2	0.738 (0.612-0.864)	0.064	> 0.05
Age-AST model	-	-	-		-	0.486 (0.365-0.608)	0.062	-
AP index	0.32	74.8	72.7	23.6	96.2	0.735 (0.575-0.895)	0.082	> 0.05
GP model	2.53	84.5	72.7	33.4	96.7	0.781 (0.638-0.924)	0.073

AP index: Age-platelet count ratio; AST: Aspartate aminotransferase; APRI: AST-platelet ratio; FI: Fibrosis index; GP: Globulin/platelet; FCI: Fibrosis-cirrhosis index; PPV: Positive predictive values; NPV: Negative predictive values; AUC: Area under the curve; CI: Confidence interval.