Globulin-platelet model predicts minimal fibrosis and cirrhosis in chronic hepatitis B virus infected patients

Table 4 Validity of age-platelet count ratio, aspartate aminotransferase-platelet ratio, age-aspartate aminotransferase model, fibrosis index, FIB-4 and fibrosis-cirrhosis index for prediction of minimal fibrosis (F0-F1) and comparison with globulin/platelet model

Fibrosis test	Cutoff value	Specificity %	Sensitivity %	PPV %	NPV %	AUC (95% CI)	Standard error	P value(vs GP model)
FI	1.58	41.1	89.7	61.2	79.4	0.695 (0.600-0.791)	0.049	> 0.05
APRI	0.85	87.5	41.4	77.4	59.0	0.635 (0.533-0.738)	0.052	< 0.05
FIB-4	1.7	85.7	51.7	78.9	63.1	0.720 (0.627-0.813)	0.047	> 0.05
FCI	0.17	80.4	55.2	74.5	63.4	0.692 (0.594-0.790)	0.050	> 0.05
Age-AST model	-	19.6	94.8	55.0	78.4	0.524 (0.417-0.632)	0.055	< 0.001
AP index	0.17	46.4	89.7	63.4	81.3	0.726 (0.634-0.818)	0.047	> 0.0
GP model	1.68	69.6	72.4	71.2	70.8	0.762 (0.676-0.848)	0.044

AP index: Age-platelet count ratio; AST: Aspartate aminotransferase; APRI: AST-platelet ratio; FI: Fibrosis index; GP: Globulin/platelet; FCI: Fibrosis-cirrhosis index; PPV: Positive predictive values; NPV: Negative predictive values; AUC: Area under the curve; CI: Confidence interval.