Colorectal cancer screening: Comparison of transferrin and immuno fecal occult blood test

Table 3 Sensitivity, specificity, positive likelihood ratio and odd ratio of three fecal occult blood tests for detection of colorectal cancer, precancerous lesions and colorectal cancer + precancerous lesions

Test	No. of neoplasms detected	Sensitivity%		Specificity%		Likely ratio(+) (95% CI)	Odd ratio (95% CI)
		n/total	% (95% CI)	n/total	% (95% CI)
CRC
g-FOBT	25	25/25	100 (86.7-100)	367/586	62.6 (58.6-66.5)	2.7 (2.4-3.0)	-
Tf	25	23/25	92 (75.0-97.8)	422/586	72 (68.2-75.5)	3.3 (2.8-3.9)	29.6 (6.8-126.9)
IFOBT	25	24/25	96 (80.5-99.3)	422/586	72 (68.2-75.5)	3.4 (2.9-4.0)	61.8 (8.3-460.2)
Tf+ IFOBT	25	25/25	100 (86.7-100)	358/586	61.1 (57.1-65.0)	2.6 (2.3-2.8)	-
g-FOBT+ Tf+ IFOBT	25	25/25	100 (86.7-100)	266/586	45.4 (41.4-49.4)	1.8 (1.7-2.0)	-
Precancerous lesions
g-FOBT	60	36/60	60 (47.4-71.4)	343/551	62.3 (58.1-66.2)	1.6 (1.3-2.0)	2.5 (1.4-4.3)
Tf	60	30/60	50 (37.7-62.3)	394/551	71.5 (67.6-75.1)	1.8 (1.3-2.3)	2.5 (1.5-4.3)
IFOBT	60	35/60	58.3 (45.7-70.0)	398/551	72.2 (68.4-75.8)	2.1 (1.6-2.7)	3.6 (2.1-6.3)
Tf+ IFOBT	60	40/60	66.7 (54.1-65.3)	338/551	61.3 (57.2-65.3)	1.7 (1.4-2.1)	3.2 (1.8-5.6)
g-FOBT+ Tf+ IFOBT	60	50/60	83.3 (72.0-90.7)	256/551	46.5 (42.3-50.6)	1.6 (1.4-1.8)	4.3 (2.2-8.7)
CRC+ precancerous lesions
g-FOBT	85	61/85	71.8 (61.4-80.2)	343/526	65.2 (61.0-69.2)	2.1 (1.7-2.5)	4.8 (2.9-7.9)
Tf	85	53/85	62.4 (51.7-72.0)	392/526	74.5 (70.6-78.1)	2.5 (2.0 -3.1)	4.8 (3.0-7.8)
IFOBT	85	59/85	69.4 (59.0-78.2)	397/526	75.5 (71.6-79.0)	2.8 (2.3-3.5)	7.0 (4.2-11.5)
Tf+ IFOBT	85	65/85	76.5 (66.4-84.2)	338/526	64.3 (60.1-68.2)	2.1 (1.8-2.5)	5.8 (3.4-9.9)
g-FOBT+ Tf+ IFOBT	85	75/85	88.2 (79.7-93.5)	256/526	48.7 (44.4-53.0)	1.7 (1.5-1.9)	7.1 (3.6-14.1)

Tf: Transferrin; IFOBT: Immuno fecal occult blood test; g-FOBT: Guaiac-fecal occult blood test; CRC: Colorectal cancer; CI: Confidence interval.