Family history influences the early onset of hepatocellular carcinoma

doi:10.3748/wjg.v18.i21.2661

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Jun 7, 2012 (publication date) through Jan 31, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 7, 2012; 18(21): 2661-2667
Published online Jun 7, 2012. doi: 10.3748/wjg.v18.i21.2661

Table 1 General characteristics of the study population n (%)

		Totaln = 2242	FHx (-)n = 2077 (92.6%)	FHx (+)n = 165 (7.4%)	P value
Gender	Male	1765 (78.7)	1639 (78.9)	126 (76.4)	0.441
	Female	477 (21.3)	438 (21.1)	39 (23.6)
Age	Median (min-max)	57.0 (18.0-89.0)	57.0 (18.0-89.0)	52.0 (29.0-79.0)	< 0.0001
	< 20	1 (0.1)	1 (0.1)	0 (0.0)	< 0.001
	20-29	13 (0.5)	12 (0.6)	1 (0.6)
	30-39	112 (5.0)	99 (4.8)	13 (7.9)
	40-49	458 (20.4)	410 (19.7)	48 (29.1)
	50-59	722 (32.2)	661 (31.8)	61 (37.0)
	60-69	640 (28.6)	606 (29.2)	34 (20.6)
	70-79	256 (11.4)	248 (11.9)	8 (4.8)
	≥ 80	40 (1.8)	40 (1.9)	0 (0.0)
Etiology	HBV	1683 (75.1)	1548 (74.5)	135 (81.8)	0.236
	HCV	296 (13.2)	280 (13.5)	16 (9.6)
	Alcohol	70 (3.1)	68 (3.3)	2 (1.2)
	Combined	32 (1.4)	31 (1.5)	1 (0.6)
	Others	50 (2.2)	45 (2.2)	5 (3.0)
	Unknown	111 (5.0)	105 (5.0)	6 (3.6)
HBV	HBV (+)	1713 (76.4)	1577 (75.9)	136 (82.4)	0.058
	HBV (-)	529 (23.6)	500 (24.1)	29 (17.6)
HCV	HCV (+)	315 (14.1)	298 (14.3)	17 (10.3)	0.15
	HCV (-)	1927 (85.9)	1779 (86.7)	148 (89.6)
Stage	I	185 (8.3)	167 (8.0)	18 (10.9)	0.221
	II	655 (29.2)	602 (29.0)	54 (32.7)
	III	648 (28.9)	610 (29.4)	38 (23.1)
	IVa and IVb	753 (33.6)	698 (33.6)	55 (33.3)
Lab,	ALT (U/L)	47.0 (3.0-3505.0)	47.0 (3.0-3505.0)	47.5 (3.0-840.0)	0.987
median (min-max)	TB (mg/mL)	1.1 (0.1-47.6)	1.1 (0.1-47.6)	1 (0.1-26.0)	0.868
	Alb (g/dL)	3.5 (1.2-9.6)	3.5 (1.2-9.6)	3.7 (1.6-5.0)	0.106
	Platelet (x 10³/μL)	121.5 (8.0-1084.0)	121.0 (18.0-1084.0)	133.0 (8.0-635.0)	0.181
Tumor markers,	AFP (ng/ mL)	69.1 (0.0-529 470.0)	67.00 (0.0-529 470.0)	110.8 (1.1-53 606.0)	0.972
median (min-max)	PIVKA-II (Mau/mL)	88.0 (1.0-16 636.8)	92.0 (1.0-16 636.8)	80.0 (6.0-2000.0)	0.990

AFP: Alpha-fetoprotein; Alb: Serum albumin; ALT: Alanine transaminase; HBV: Hepatitis B virus; HCV: Hepatitis C virus; FHx: Family history; PIVKA-II: Protein induced by vitamin K deficiency-II; TB: Serum total bilirubin.

Citation: Park CH, Jeong SH, Yim HW, Kim JD, Bae SH, Choi JY, Yoon SK. Family history influences the early onset of hepatocellular carcinoma. World J Gastroenterol 2012; 18(21): 2661-2667
URL: https://www.wjgnet.com/1007-9327/full/v18/i21/2661.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i21.2661