Clinical course of sub-centimeter-sized nodules detected during surveillance for hepatocellular carcinoma

Table 3 Multivariate analysis of risk factors for the development of hepatocellular carcinoma from sub-centimeter-sized hepatic nodules

Variables	P value	OR	95% CI
Age (yr)	0.012	1.075	1.016-1.137
Male	0.009	3.969	1.403-11.226
PT (INR)	0.877	0.698	0.007-66.718
Platelets (109/L)	0.917	0.999	0.990-1.009
Albumin (g/dL)	0.478	0.624	0.169-2.298
Nodule pattern	0.081
Nodule pattern (1)1	1.000	0.812	0.233-2.827
Nodule pattern (2)2	0.054	0.075	0.006-1.026
Baseline AFP (ng/mL)	0.024	1.039	1.005-1.073

¹Between hypoechoic/low-attenuation and mixed echoic/attenuation;

²Between hyperechoic/high-attenuation and mixed echoic/attenuation. OR: Odds ratio; CI: Confidence interval; PT: Prothrombin time; AFP: Alpha-fetoprotein; INR: International normalized ratio. Data are shown as the mean ± SD, median (range) or number (%) of patients.