Suppression of esophageal cancer cell growth using curcumin, (-)-epigallocatechin-3-gallate and lovastatin

Figure 5 Reduced expression of Ki67, phosphorylated extracellular-signal-regulated kinases and cyclooxygenase-2 in xenografts following treatment of mice with or without curcumin, (-)-epigallocatechin-3-gallate, lovastatin and their combinations. Tumor cell xenografts obtained from the nude mouse experiments were processed and subjected to immunohistochemical analyses of Ki67, phosphorylated extracellular-signal-regulated kinases (Erk1/2) and cyclooxygenase-2 (COX-2) expression. Representative images were obtained in each treatment group. EGCG: (-)-epigallocatechin-3-gallate; L: Lovastatin; Cur: Curcumin.