Matrix metalloproteinase-9 contributes to parenchymal hemorrhage and necrosis in the remnant liver after extended hepatectomy in mice

Figure 5 Histological analysis in each strain. Histological analysis between wild-type (WT, n = 15) (A), matrix metalloproteinase (MMP)-9(-/-) (n = 15) (B), and tissue inhibitors of metalloproteinases (TIMP)-1 (-/-) mice (n = 14) (C) at 6 h after 80%-partial hepatectomy (PH). Representative images of remnant liver histology at 6 h after 80%-PH in WT, MMP-9(-/-), and TIMP-1(-/-) mice. Foci of hemorrhage and necrosis are denoted by white arrows. The percentage of the necrotic area (D) and the number of necrotic foci per mm² (E) in remnant livers of study mice are shown. Significantly smaller and fewer necrotic foci in the remnant liver were observed in MMP-9(-/-) mice compared with WT and TIMP-1(-/-) mice (^aP < 0.05, ^bP < 0.01).