Matrix metalloproteinase-9 contributes to parenchymal hemorrhage and necrosis in the remnant liver after extended hepatectomy in mice

Figure 1 Histological and hematological differences between groups I and II at 6 h after 80%-partial hepatectomy. A: Histological findings in group I mice; B: Representative images of remnant liver histology demonstrating significant multiple foci of hemorrhage and necrosis in group II mice; C: Quantitation of the size (area percentage) of hemorrhage and necrosis: Significantly larger areas and more hemorrhagic and necrotic foci were observed in group II mice than in group I mice (^aP < 0.05); D: Quantitation of the number of foci of hemorrhage and necrosis per mm²: Significantly larger areas and more hemorrhagic and necrotic foci were observed in group II mice than in group I mice (^bP < 0.01); E: Aspartate aminotransferase (AST) levels were significantly higher in group II mice than those in group I mice (^aP < 0.05); F: Alanine aminotransaminase (ALT) levels were significantly higher in group II mice than those in group I mice (^aP < 0.05); G: Total bilirubin levels were significantly higher in group II mice than those in group I mice (^bP < 0.01).