Pathogenesis of NSAID-induced gastric damage: Importance of cyclooxygenase inhibition and gastric hypermotility

Figure 12 Effects of various drugs on prostaglandin E₂ production and cyclooxygenase-2 expression in rat gastric mucosa. A: Effects of various drugs on prostaglandin E₂ (PGE₂) levels in the rat gastric mucosa at 8 h after administration of SC-560. The animals were administered SC-560 (10 mg/kg) p.o., and killed 2 or 8 h later. Rofecoxib (30 mg/kg) was given p.o. together with SC-560 while omeprazole (OM, 30 mg/kg) or atropine (AT, 3 mg/kg) was given s.c. 1 h before the administration of SC-560. Data are presented as the mean ± SE in 6 rats. Significant difference at P < 0.05; ^afrom control; ^cfrom SC-560 (2 h); ^efrom vehicle; B: Effect of OM and AT on cyclooxygenase (COX)-2 expression after administration of indomethacin (IM) in rat stomach. The animals were administered IM (30 mg/kg) p.o., and killed 4 h later. OM (30 mg/kg) or AT (3 mg/kg) was given s.c. 1 h before indomethacin. Some animals were given 1 mL of 100 mmol HCl immediately after administration of IM. GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; M: Marker, V: Vehicle (data from ref. 48 after modification).