Pathogenesis of NSAID-induced gastric damage: Importance of cyclooxygenase inhibition and gastric hypermotility

Figure 11 Gene expression of cyclooxygenase-1 and cyclooxygenase-2 in rat gastric mucosa after administration of various non-steroidal anti-inflammatory drugs (A) or various cyclooxygenase inhibitors (B). The animals were given indomethacin (IM, 30 mg/kg), naproxen (NAP, 40 mg/kg), flurbiprofen (FLU, 20 mg/kg), dicrofenac (DIC, 40 mg/kg), SC-560 (SC, 30 mg/kg), or rofecoxib (Rof, 30 mg/kg) p.o., and the expression of cyclooxygenase (COX)-1 and COX-2 mRNA was examined by reverse transcription polymerase chain reaction 4 h later. GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; M: Marker, V: Vehicle (data from refs. 18 and 19 after modification).