Pathogenesis of NSAID-induced gastric damage: Importance of cyclooxygenase inhibition and gastric hypermotility

Figure 9 Gastric ulcerogenic responses to various cyclooxygenase inhibitors and their effects on prostaglandin E₂ content in rat stomachs. A: Gastric ulcerogenic responses induced by various cyclooxygenase (COX) inhibitors in rat stomach. The animals were given indomethacin (nonselective COX inhibitor; 10 and 30 mg/kg), SC-560 (selective COX-1 inhibitor; 10 and 30 mg/kg), or rofecoxib (selective COX-2 inhibitor; 10 and 30 mg/kg) p.o. and killed 8 h later; B: Effects of various COX inhibitors on gastric mucosal prostaglandin E₂ (PGE₂) content in rats. The animals were given indomethacin (10 mg/kg), SC-560 (10 mg/kg), or rofecoxib (10 mg/kg) p.o. and killed 2 h later. Data are presented as the mean ± SE in 5-6 rats. ^aP < 0.05 vs control (data from refs. 18 and 19 after modification).