Pathogenesis of NSAID-induced gastric damage: Importance of cyclooxygenase inhibition and gastric hypermotility

Figure 5 Time-course of changes in gastric lesions following administration of indomethacin (30 mg/kg, s. c.) in rats, with or without pretreatment. Atropine (1 mg/kg) was given s.c. 30 min before indomethacin, while dmPGE₂ (10 μg/kg) or anti-neutrophil antiserum (ANS, 0.2 mL/rat) was given i.v. 10 min and 1 h, respectively, before indomethacin. Data are presented as the mean ± SE in 4-6 rats. ^aP < 0.05 vs control group given normal serum (data from ref. 28 after modification).