Pathogenesis of NSAID-induced gastric damage: Importance of cyclooxygenase inhibition and gastric hypermotility

Figure 2 Effects of atropine, cimetidine and omeprazole on gastric lesions produced by indomethacin in rats. The animals were given indomethacin (30 mg/kg, s.c.) and killed 4 h later. Omeprazole (30 mg/kg), cimetidine (100 mg/kg) and atropine (3 mg/kg, s.c.) were given 1 h before indomethacin. In some cases, the animals were given 1 mL of 100 mmol HCl p.o. immediately after the administration of indomethacin. Data are presented as the mean ± SE for 5-8 rats. ^aP < 0.05 vs vehicle (data from refs. 6, 26 and 27 after modification).