Clinical significance of connective tissue growth factor in hepatitis B virus-induced hepatic fibrosis

doi:10.3748/wjg.v18.i18.2280

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May 14, 2012 (publication date) through Nov 8, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 14, 2012; 18(18): 2280-2286
Published online May 14, 2012. doi: 10.3748/wjg.v18.i18.2280

Table 2 Relationship between fibrosis stage and hepatic or serum connective tissue growth factor content

Fibrosis stage	n	Serum CCN2(μg/L) median (95% CI)	Hepatic CCN2 mRNA(IOD) median (95% CI)
Normal control	8	2.2 (1.5-2.9)	6.0 (3.9-8.8)
F1	11	6.8 (5.0-8.9)	19.4 (12.3-26.4)
F2	9	8.9 (7.1-10.7)	25.6 (13.9-34.8)
F3	11	9.4 (7.3-12.0)	31.9 (19.7-44.6)
F4	8	10.1 (8.2-12.1)	39.6 (25.5-52.8)

Normal Control samples were from hepatitis B virus carriers and had normal liver histology; F1-F2: Mild fibrosis; F3-F4: Significant fibrosis. CCN2: Connective tissue growth factor; IOD: integrated optimal density.

Citation: Piao RL, Brigstock DR, Zhu J, Zhang ML, Gao RP. Clinical significance of connective tissue growth factor in hepatitis B virus-induced hepatic fibrosis. World J Gastroenterol 2012; 18(18): 2280-2286
URL: https://www.wjgnet.com/1007-9327/full/v18/i18/2280.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i18.2280