Effect of soy protein supplementation in patients with chronic hepatitis C: A randomized clinical trial

doi:10.3748/wjg.v18.i18.2203

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May 14, 2012 (publication date) through Feb 14, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 14, 2012; 18(18): 2203-2211
Published online May 14, 2012. doi: 10.3748/wjg.v18.i18.2203

Table 2 Characterization of the study population n (%)

	CG-casein	IG-soy	Total	P value
Demographic characteristics
Gender
Male	49 (61.2)	53 (66.2)	102 (63.8)	0.62¹
Female	31 (38.8)	27 (33.8)	58 (36.2)
Marital Status
Married	56 (70.0)	55 (68.7)	111 (69.4)	1.00¹
Single, widowed or divorced	24 (30.0)	25 (31.3)	49 (30.6)
Anthropometric data
Body mass index
< 25 kg/m²	40 (50.0)	43(53.8)	83 (51.9)	0.751¹
≥ 25 kg/m²	40 (50.0)	37(46.2)	77 (48.1)
Waist circumference
Adequate	43 (53.7)	46 (59.0)	89 (56.3)	0.525¹
Inadequate	37 (46.3)	32 (41.0)	69 (43.7)
Clinical data
Genotype
1	66 (88.0)	61 (79.2)	127 (83.5)	0.189¹
2/3	9 (12.0)	16 (20.8)	25 (16.5)
Necroinflammatory activity
A0	26 (41.3)	29 (46.8)	55 (44.0)	0.792¹
A1	26 (41.3)	22 (35.5)	48 (38.4)
A2 e A3	11 (17.4)	11 (17.7)	22 (17.6)
Stage of fibrosis
F0/F1/F2	35 (55.6)	40 (63.5)	75 (59.5)	0.468¹
F3/F4	28 (44.4)	23 (36.5)	51 (40.5)
Hepatic steatosis
Yes	24 (40.0)	19 (29.7)	43 (34.7)	0.260¹
No	36 (60.0)	45 (70.3)	81 (65.3)
HOMA-IR
< 3.0	55 (53.9)	47 (46.1)	102 (63.7)	0.25¹
≥ 3.0	25 (43.1)	33 (56.9)	58 (36.3)
Biochemical data	Median (iq r)	Median (iq r)
Glucose (mg/dL)	91.0 (14.2)	91.5 (14.2)		0.70²
HOMA-IR	2.35 (2.24)	2.26 (2.59)		0.99²
Triglycerides (mg/dL)	96.5 (60.2)	96.0 (67.2)		0.57²
Total cholesterol (mg/dL)	149.0 (49.7)	160.0 (44.0)		0.42²
HDL (mg/dL)	44.0 (14.2)	44.0 (15.5)		0.30²
LDL (mg/dL)	90.5 (40.7)	90.0 (43.0)		0.94²
AST (U/L)	59.5 (40.7)	52.0 (44.5)		0.14²
ALT (U/L)	76.5 (54.5)	73.5 (53.0)		0.38²
γGT (U/L)	102.0 (118.0)	87.0 (114.0)		0.71²
Alkaline phosphatase (U/L)	79.0 (33.5)	80.0 (53.2)		0.49²

¹Fisher’s exact test;

²Mann-Whitney; iq r: Interquartile range. n = 160. CG-casein: Control group-casein; IG-soy: Intervention group-soy; Adequate waist circumference: ≤ 80 cm for women and ≤ 94 cm for men. HOMA-IR: Homeostasis model assessment index of insulin resistance; HDL: High density lipoprotein; LDL: Low density lipoprotein; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; γGT: Gamma glutamyl transferase.

Citation: Oliveira LP, Jesus RP, Boulhosa RS, Mendes CMC, Gnoatto MC, Lemaire DC, Toralles MBP, Cavalcante LN, Lyra AC, Lyra LG. Effect of soy protein supplementation in patients with chronic hepatitis C: A randomized clinical trial. World J Gastroenterol 2012; 18(18): 2203-2211
URL: https://www.wjgnet.com/1007-9327/full/v18/i18/2203.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i18.2203