Association of NOD1 and NOD2 genes polymorphisms with Helicobacter pylori related gastric cancer in a Chinese population

Table 7 Associations of NOD1 diplotypes and gastric cancer with two major types and Helicobacter pylori infection status

	Diplotype
	AGT/AAA	AAA/GGA	AGT/GGA	AGT/AGT	GGA/GGA	AAA/AAA	Others
HP+ GC (n = 221)	34 (15)	35 (16)	41 (19)	54 (24)	18 (8)	22 (10)	17 (8)
HP+ GA (n = 119)	32 (27)	22 (18)	18 (15)	17 (14)	16 (13)	7 (6)	7 (6)
AOR1 (95% CI)	1	1.49 (0.72-3.08)	2.14 (1.01-4.51)a	3.07 (1.47-6.41)a	1.09 (0.47-2.53)	2.96 (1.10-7.92)a	2.44 (0.89-6.71)
P		0.28	0.05a	0.002ab	0.83	0.03a	0.08
Diffuse GC (n = 125)	21 (17)	17 (14)	26 (21)	30 (24)	8 (6)	16 (13)	7 (6)
GA (n = 160)	38 (24)	35 (22)	25 (16)	21 (13)	20 (13)	12 (8)	9 (6)
AOR (95% CI)	1	0.84 (0.38-1.88)	1.66 (0.76-3.61)	2.56 (1.17-5.58)a	0.66 (0.24-1.77)	2.01 (0.78-5.16)	1.33 (0.43-4.14)
P		0.68	0.20	0.02a	0.41	0.15	0.62
Intestinal GC (n = 129)	29 (23)	22 (17)	25 (19)	22 (17)	11 (9)	12 (9)	8 (6)
GA (n = 160)	38 (24)	35 (22)	25 (16)	21 (13)	20 (13)	12 (8)	9 (6)
AOR (95% CI)	1	0.83 (0.40-1.73)	1.64 (0.76-3.54)	1.43 (0.65-3.14)	0.84 (0.34-2.06)	1.62 (0.619-4.26)	1.13 (0.38-3.34)
P		0.62	0.20	0.38	0.69	0.32	0.83
HP+ diffuse GC (n = 93)	12 (13)	13 (14)	19 (20)	26 (28)	7 (8)	10 (11)	6 (7)
HP+ GA (n = 119)	32 (27)	22 (19)	18 (15)	17 (14)	16 (13)	7 (6)	7 (6)
AOR (95% CI)	1	1.42 (0.53-3.76)	2.36 (0.91-6.08)	4.02 (1.61-10.05)a	1.09 (0.35-3.38)	3.12 (0.94-10.40)	2.30 (0.63-8.44)
P		0.48	0.08	0.002ab	0.88	0.06	0.21

¹ORs were adjusted for the covariates (age, sex and/or Helicobacter pylori infection);

²Remained significant after Bonferroni adjustment for multiple comparisons. GC: Gastric cancer group; GA: Gastritis group.

^aP < 0.05,

^bP < 0.01, GC vs GA.