Association of NOD1 and NOD2 genes polymorphisms with Helicobacter pylori related gastric cancer in a Chinese population

Table 4 Association of the risk single nucleotide polymorphisms in NOD1and NOD2 with two major gastric cancer types and Helicobacter pylori infection status

Type	Genotype			Heterozygote		Homozygote		Dominant model		Recessive model
	AA1	Aa	aa	AOR2 (95% CI)	P	AOR (95% CI)	P	AOR (95% CI)	P	AOR (95% CI)	P
NOD1 rs2907749 risk allele:A
Diffuse 125 cases	68	49	8	2.24 (0.91-5.53)	0.08	2.66 (1.10-6.44)	0.03a	2.47 (1.05-5.81)	0.04a	1.39 (0.86-2.24)	0.18
Intestinal 129 cases	66	52	11	1.61 (0.71-3.67)	0.26	1.58 (0.71-3.55)	0.27	1.59 (0.73-3.46)	0.24	1.09 (0.68-1.75)	0.72
160 controls	91	61	8	/	/	/	/	/	/	/	/
NOD1 rs2075820 risk allele:G
Diffuse 125 cases	60	55	13	0.45 (0.19-1.07)	0.07	0.82 (0.36-1.90)	0.65	0.63 (0.28-1.41)	0.26	1.55 (0.96-2.51)	0.08
Intestinal 128 cases	68	41	16	0.54 (0.22-1.31)	0.17	0.77 (0.32-1.85)	0.56	0.65 (0.28-1.51)	0.32	1.29 (0.79-2.08)	0.31
158 controls	68	78	12	/	/	/	/	/	/	/	/
HP+ 220 cases	119	78	23	0.39 (0.16-0.99)	0.05	0.674 (0.27-1.68)	0.40	0.53 (0.22-1.28)	0.16	1.47 (0.93-2.31)	0.10
HP+ diffuse 93 cases	56	27	10	0.38 (0.13-1.13)	0.08	0.85 (0.29-2.46)	0.76	0.60 (0.21-1.70)	0.34	1.89 (1.07-3.32)	0.03a
HP+ 117 controls	52	58	7	/	/	/	/	/	/	/	/
NOD1 rs7789045 risk allele:T
Diffuse 125 cases	32	51	42	1.36 (0.79-2.33)	0.26	2.97 (1.49-5.95)	0.00ab	1.719 (1.045-2.828)	0.03a	2.53 (1.35-4.74)	0.00ab
Intestinal 129 cases	22	60	47	1.39 (0.83-2.32)	0.21	1.55 (0.76-3.16)	0.23	1.42 (0.88-2.31)	0.15	1.31 (0.67-2.53)	0.43
160 controls	20	85	55	/	/	/	/	/	/	/	/
HP+ 221 cases	56	86	79	0.99 (0.60-1.62)	0.96	2.05 (1.07-3.94)	0.03a	1.24 (0.79-1.97)	0.35	2.06 (1.13-3.76)	0.02a
HP+ diffuse 93 cases	28	34	31	1.06 (0.56-2.01)	0.87	3.00 (1.38-6.53)	0.01ab	1.50 (0.84-2.69)	0.17	2.91 (1.45-5.87)	0.00ab
HP+ 119 controls	17	53	49	/	/	/	/	/	/	/	/
NOD2 rs3135500 risk allele:G
HP+ 221 cases	132	79	10	2.65 (1.02-6.89)	0.05a	2.20 (0.88-5.51)	0.091	2.35 (0.96-5.79)	0.06	0.98 (0.62-1.55)	0.92
HP+ 119 controls	73	35	11	/	/	/	/	/	/	/	/
NOD2 rs7205423 risk allele:C
HP+ 221 cases	112	97	12	2.52 (1.05-6.04)	0.04a	2.26 (0.96-5.35)	0.06	2.38 (1.03-5.48)	0.04a	1.04 (0.66-1.63)	0.88
HP+ 119 controls	61	45	13	/	/	/	/	/	/	/	/

¹Genotypes are shown as AA for risk allele homozygotes, Aa for heterozygotes and aa for the nonrisk allele homozygotes;

²ORs were adjusted for the covariates (age, sex and/or Helicobacter pylori infection).

^aP < 0.05,

^bP < 0.01, cases vs controls.