Association of NOD1 and NOD2 genes polymorphisms with Helicobacter pylori related gastric cancer in a Chinese population

Table 3 Adjusted odds ratios for gastric cancer associated with NOD1 and NOD2 polymorphisms

Gene	rsID	Chr	11	21	GC group	GA group	AOR2 (95% CI)
							Heterozygote	Homozygote	Dominant	Recessive
					11/12/22	11/12/22
NOD1	rs17159048	7	G	T	1/62/233	3/38/1183	0.82 (0.52-1.31)	/	0.78 (0.49-1.22)	/
	rs2907749	7	G	A	23/117/156	22/62/76	0.92 (0.61-1.39)	0.50 (0.26-0.95)a	0.81 (0.55-1.19)	0.52 (0.28-0.96)a
	rs2075820	7	A	G	32/118/1453	12/78/683	0.70 (0.47-1.06)	1.27 (0.62-2.64)	0.78 (0.53-1.16)	1.51 (0.75-3.04)
	rs7789045	7	T	A	65/126/105	21/67/72	1.30 (0.85-1.99)	2.14 (1.20-3.82)a	1.50 (1.01-2.22)a	1.87 (1.09-3.20)a
NOD2	rs2067085	16	G	C	0/46/250	0/24/136	1.04 (0.61-1.78)	/	/	/
	rs1861759	16	C	A	8/69/219	3/43/114	0.79 (0.50-1.23)	1.29 (0.33-4.97)	0.82 (0.53-1.27)	/
	rs3135500	16	A	G	16/111/169	12/51/97	1.22 (0.80-1.85)	0.73 (0.33-1.61)	1.13 (0.76-1.67)	0.68 (0.31-1.47)
	rs7205423	16	G	C	20/135/141	14/61/85	1.31 (0.87-1.96)	0.82 (0.39-1.72)	1.22 (0.82-1.79)	0.72 (0.35-1.48)

¹"1"designates the minor allele,"2"designates the major allele;

²ORs were adjusted for the covariates (age, sex and Helicobacter pylori infection);

³One or two subjects failed to be genotyped. GC: Gastric cancer group; GA: Gastritis group.

^aP < 0.05, GC vs GA.