Over-expression of uPA increases risk of liver injury in pAAV-HBV transfected mice

Figure 6 Comparison of the serum hepatitis B e antigen, hepatitis B surface antigen, interleukin-6, tumor necrosis factor-α, alanine aminotransferase levels and hepatic α-fetoprotein mRNA levels between mice from different groups. Group 1: Adeno-associated virus (AAV)-internal ribosome entry site transfected doxycycline (Dox)-induced in-alb-urokinase plasminogen activator (uPA) mice (n = 6); Group 2: AAV-hepatitis B virus (HBV) transfected non-induced in-alb-uPA mice (n = 6); Group 3: AAV-HBV transfected Dox-induced in-alb-uPA mice (n = 6). HBeAg: Hepatitis B e antigen; HBsAg: Hepatitis B surface antigen; ALT: Alanine aminotransferase; IL: Interleukin; TNF: Tumor necrosis factor; AFP: α-fetoprotein.