Over-expression of uPA increases risk of liver injury in pAAV-HBV transfected mice

Figure 5 Synergistic injury of liver in in-alb-urokinase plasminogen activator transgenic mice after adeno-associated virus-1. 3hepatitis B virus transfection. Histological and immunohistochemical staining for hepatitis B core antigen in the livers of different groups of mice 20 d later after adeno-associated virus (AAV)-1.3hepatitis B virus (HBV) transfection. A: Histology of the AAV-internal ribosome entry site (IRES) transfected doxycycline (Dox)-induced in-alb-urokinase plasminogen activator (uPA) mice; B: Histology of the AAV-HBV transfected non-induced in-alb-uPA mice; C: Histology of the AAV-HBV transfected Dox-induced in-alb-uPA mice; D: Double-staining immunohistochemical analysis of the AAV-IRES transfected Dox-induced in-alb-uPA mice; E: Double-staining immunohistochemical analysis of the AAV-HBV transfected non-induced in-alb-uPA mice; F: Double-staining immunohistochemical analysis of the AAV-HBV transfected Dox-induced in-alb-uPA mice. Magnification, × 20.