Antithrombin III injection via the portal vein suppresses liver damage

doi:10.3748/wjg.v18.i16.1884

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Apr 28, 2012 (publication date) through Dec 15, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 28, 2012; 18(16): 1884-1891
Published online Apr 28, 2012. doi: 10.3748/wjg.v18.i16.1884

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Figure 1 Effects of antithrombin III on serum alanine aminotransferase levels in rats with acute liver failure. Lipopolysaccharide (LPS) and D-galactosamine (GalN) were injected intraperitoneally into 8-wk-old Wistar rats. One hour after the challenge, antithrombin (AT) III (50 U/kg body weight) was injected into the portal or tail vein. Serum alanine aminotransferase (ALT) levels were measured at 6 h, 12 h and 24 h after injection of LPS and GalN. Control: Untreated; TV: AT III injection via the tail vein; PV: AT III injection via the portal vein. Values are mean ± SD (n = 10 rats/group). ^aP < 0.01 vs the control group.

Citation: Miyazaki M, Kato M, Tanaka M, Tanaka K, Takao S, Kohjima M, Ito T, Enjoji M, Nakamuta M, Kotoh K, Takayanagi R. Antithrombin III injection via the portal vein suppresses liver damage. World J Gastroenterol 2012; 18(16): 1884-1891
URL: https://www.wjgnet.com/1007-9327/full/v18/i16/1884.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i16.1884