Is hepatic arterial infusion chemotherapy effective treatment for advanced hepatocellular carcinoma resistant to transarterial chemoembolization?

doi:10.3748/wjg.v18.i16.1933

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Apr 28, 2012 (publication date) through Feb 24, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 28, 2012; 18(16): 1933-1939
Published online Apr 28, 2012. doi: 10.3748/wjg.v18.i16.1933

Table 2 Comparison of the patient characteristics in the two groups prior to hepatic arterial infusion chemotherapy n (%)

	Group A	Group B	Pvalue
Patients	23	19
Age (yr)	66.6 ± 6.9	65.5 ± 7.3	NS (P = 0.635)
Gender
Male/female	20 (87)/3 (13)	15 (79)/4 (21)	NS (P = 0.488)
Etiology of LC
HCV	13 (57)	11 (58)	NS (P = 0.070)
HBV	2 (9)	6 (32)
HCV + HBV	0 (0)	1 (5)
Alcohol	4 (17)	0 (0)
NonB-nonC	4 (17)	1 (5)
Albumin (g/dL)	3.6 ± 0.6	3.5 ± 0.6	NS (P = 0.503)
Total bilirubin (mg/dL)	1.1 ± 0.7	1.3 ± 0.5	NS (P = 0.397)
PT (INR)	1.19 ± 0.13	1.17 ± 0.10	NS (P = 0.607)
AST (U/L)	64 ± 33	79 ± 51	NS (P = 0.256)
ALT (U/L)	47 ± 30	53 ± 38	NS (P = 0.569)
GGT (U/L)	155 ± 169	76 ± 76	NS (P = 0.067)
WBC (/μL)	4600 ± 1400	4400 ± 900	NS (P = 0.431)
Hb (g/dL)	13.1 ± 2.0	12.8 ± 1.0	NS (P = 0.521)
Plt (× 10⁴/μL)	14.3 ± 6.5	12.1 ± 5.8	NS (P = 0.262)
AFP (median, ng/mL)	7550	3116	NS (P = 0.434)
DCP (median, mAU/mL)	12314	3363	NS (P = 0.159)
Child-Pugh
A/B	12 (52)/11 (48)	6 (32)/13 (68)	NS (P = 0.219)
Child-Pugh score	6.8 ± 1.7	7.1 ± 1.4	NS (P = 0.582)
Number of tumor (s)
≤ 5/6-10/> 10	5 (22)/7 (30) /11 (48)	5 (26)/8 (42) /6 (32)	NS (P = 0.515)
Size of the largest tumor (cm)	7.3 ± 5.2	3.8 ± 1.3	P = 0.008
Vessel invasion
presence/absence	12 (52)/11 (48)	7 (37)/12 (63)	NS (P = 0.320)
Clinical stage
I/II/III/IVA	0 (0)/0 (0)/ 11 (48)/12 (52)	0 (0)/0 (0)/ 13 (68)/6 (32)	NS (P = 0.180)
Duration of treatment received prior to HAIC (mo)	16.3 ± 20.7	36.2 ± 21.5	P = 0.004
Previous number of TACE session (s)	0.9 ± 0.6	4.5 ± 1.8	P < 0.0001
HAIC regimens
5-FU, cisplatin	8 (35)	7 (37)	NS (P = 0.923)
5-FU, natural IFN-α	4 (17)	4 (21)
5-FU, PEG-IFN-α2b	11 (48)	8 (42)

HCV: Hepatitis C virus; HBV: Hepatitis B virus; LC: Liver cirrhosis; PT: Prothrombin time; INR: International ratio; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GGT: γ glutamyl transferase; AFP: α-fetoprotein; WBC: White blood cell; DCP: Des-γ-carboxyprothrombin; HAIC: Hepatic arterial infusion chemotherapy; TACE: Transarterial chemoembolization; 5-FU: 5-fluorouracil; IFN: Interferon; PEG-IFN-α2b: Pegylated interferon-α2b.

Citation: Kirikoshi H, Yoneda M, Mawatari H, Fujita K, Imajo K, Kato S, Suzuki K, Kobayashi N, Kubota K, Maeda S, Nakajima A, Saito S. Is hepatic arterial infusion chemotherapy effective treatment for advanced hepatocellular carcinoma resistant to transarterial chemoembolization? World J Gastroenterol 2012; 18(16): 1933-1939
URL: https://www.wjgnet.com/1007-9327/full/v18/i16/1933.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i16.1933