Gastrointestinal and hepatic complications of hematopoietic stem cell transplantation

doi:10.3748/wjg.v18.i16.1851

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Apr 28, 2012 (publication date) through Feb 21, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 28, 2012; 18(16): 1851-1860
Published online Apr 28, 2012. doi: 10.3748/wjg.v18.i16.1851

Table 6 Risk factors for sinusoidal obstruction syndrome

Existing liver disease:

Chronic viral hepatitis

Alcohol related hepatitis

Steatohepatitis

Cirrhosis, lobular fibrosis

Cholestatic disorders

Extramedullary hematopoiesis with sinusoidal fibrosis

Prior history of:

SOS

Extensive chemotherapy and stem cell transplantation

Hepatic radiation

Drugs

Recent gemtuzumab ozogamicin use

Conditioning agents:

High dose TBI (> 14 Gy)

Cyclophosphamide metabolite: acrolein

Busulfan

Melphalan

Concomitant use of sirolimus during conditioning

SOS: Sinusoidal obstruction syndrome; TBI: Total body irradiation.

Citation: Tuncer HH, Rana N, Milani C, Darko A, Al-Homsi SA. Gastrointestinal and hepatic complications of hematopoietic stem cell transplantation. World J Gastroenterol 2012; 18(16): 1851-1860
URL: https://www.wjgnet.com/1007-9327/full/v18/i16/1851.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i16.1851