Diazoxide attenuates ischemia/reperfusion injury via upregulation of heme oxygenase-1 after liver transplantation in rats

Figure 4 Liver histology and ultrastructural changes of hepatocytes. A: Ischemia/reperfusion (I/R) treated livers showed vacuolization, nuclear fragmentation, sinusoidal congestion, and hepatocyte necrosis. However, histological tissue damage was aggravated in the small interfering RNA (siRNA) and siRNA + diazoxide (DZ) groups. In contrast, DZ treatment relieved liver damage (HE, × 400); B: The mitochondria and the smooth endoplasmic reticulum were dilated and even destroyed, and the mitochondrial cristae were disorganized in I/R treated hepatocytes.