Pro-apoptotic effects of tectorigenin on human hepatocellular carcinoma HepG2 cells

doi:10.3748/wjg.v18.i15.1753

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Apr 21, 2012 (publication date) through Jul 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 21, 2012; 18(15): 1753-1764
Published online Apr 21, 2012. doi: 10.3748/wjg.v18.i15.1753

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Figure 11 Possible mechanisms by which tectorigenin induces apoptosis in human hepatocellular carcinoma HepG2 cells. Tectorigenin produces reactive oxygen species and increases Ca²⁺ concentration in cytoplasm of HepG2 cells, leading to the depletion of mitochondrial membrane potential and release of cytochrome c from mitochondria. Cytochrome c facilitates apoptosis of HepG2 cells by activating caspase cascade. Tec: Tectorigenin; ROS: Reactive oxygen species; C: Cytochrome c; Casp: Caspase; AIF: Apoptosis inducing factor; MMP: Mitochondrial membrane potential.

Citation: Jiang CP, Ding H, Shi DH, Wang YR, Li EG, Wu JH. Pro-apoptotic effects of tectorigenin on human hepatocellular carcinoma HepG2 cells. World J Gastroenterol 2012; 18(15): 1753-1764
URL: https://www.wjgnet.com/1007-9327/full/v18/i15/1753.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i15.1753