Macrophage secretory products induce an inflammatory phenotype in hepatocytes

Table 4 The 21 most differentially expressed genes between control and macrophage-conditioned media-treated HepG2 cells as determined by microarray

Gene		Fold change	Differential expression	P value
Lipocalin-2	Lipocalin-2	17.8	↑	< 1E-07
TIMP1	Metallopeptidase inhibitor 1	11.8	↑	< 1E-07
UBD	Ubiquitin D	10.9	↑	< 1E-07
SERPINA3	Serpin peptidase inhibitor clade A member 3	7.5	↑	< 1E-07
IGFBP1	Insulin-like growth factor binding protein 1	7.5	↑	< 1E-07
S100A3	S100 calcium binding protein A3	6.6	↑	< 1E-07
RASD1	RAS dexamethasone-induced 1	6.4	↑	< 1E-07
CEBPD	CCAAT/enhancer binding protein delta	6.2	↑	< 1E-07
SERPINE1	Serpin peptidase inhibitor clade E member 1	5.9	↑	9.00E-07
NDRG1	N-myc downstream regulated gene 1	4.8	↑	< 1E-07
EMP3	Epithelial membrane protein 3	4.6	↑	< 1E-07
DUSP5	Dual specificity phosphatase 5	4.6	↑	< 1E-07
SOD2	Superoxide dismutase 2, mitochondrial	4.4	↑	< 1E-07
F2RL1	Coagulation factor II receptor-like 1	4.4	↑	< 1E-07
CCL20	Chemokine ligand 20	4.2	↑	< 1E-07
SDC4	Syndecan 4	4.1	↑	6.00E-07
TGM2	Transglutaminase 2	4.1	↑	< 1E-07
NR1H4	Nuclear receptor subfamily 1, group H, member 4	4.2	↓	< 1E-07
LIME1	Lck interacting transmembrane adaptor 1	4.2	↓	1.00E-07
DDC	Dopa decarboxylase	4.3	↓	< 1E-07
ANKRD38	Ankyrin repeat domain 38	5.1	↓	< 1E-07