Macrophage secretory products induce an inflammatory phenotype in hepatocytes

doi:10.3748/wjg.v18.i15.1732

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Apr 21, 2012 (publication date) through Dec 27, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 21, 2012; 18(15): 1732-1744
Published online Apr 21, 2012. doi: 10.3748/wjg.v18.i15.1732

Table 3 Selected altered gene ontology, KEGG and BioCarta pathways

	ID	Biological process (no. genes)	Differential expression	P value^a
Gene ontology	0034097	Response to cytokine stimuli (80)	↑	0.00125
	0034341	Response to interferon-γ (11)	↑	0.00165
	0000302	Response to reactive oxygen species (73)	↑	0.00123
	0031663	LPS-mediated signalling pathway (12)	↑	0.00144
	0019882	Antigen processing and presentation (58)	↑	0.00172
	0032393	MHC class I receptor activity (15)	↑	0.00160
	0019217	Regulation of fatty acid metabolic process (48)	↓	0.00127
KEGG	hsa00071	Fatty acid metabolism (51)	↓	0.00001
	hsa00120	Bile acid biosynthesis (41)	↓	0.00001
BioCarta	h_tnfr2Pathway	TNFR2 signaling pathway (17)	↑	0.00130
	h_ctlPathway	CTL mediated immune response against target cells (15)	↑	0.00157
	h_nkcellsPathway	Ras-independent pathway in NK-cell-mediated cytotoxicity (22)	↑	0.00179
	h_cd40Pathway	CD40L signaling pathway (15)	↑	0.00221
	h_fxrPathway	FXR and LXR regulation of cholesterol metabolism (7)	↓	0.00135

^aAverage P-value < 0.005 as measured by least-squares permutation, Kolmogorov-Smirnov permutation, Efron-Tibshirani’s gene set analysis test and Goeman’s global test. LPS: Lipopolysaccharide; TNFR2: Tumour necrosis factor receptor 2; NK: Natural killer; CTL: Cytotoxic lymphocyte; FXR: Farnesoid X receptor; LXR: Liver X receptor.

Citation: Melino M, Gadd VL, Walker GV, Skoien R, Barrie HD, Jothimani D, Horsfall L, Jones A, Sweet MJ, Thomas GP, Clouston AD, Jonsson JR, Powell EE. Macrophage secretory products induce an inflammatory phenotype in hepatocytes. World J Gastroenterol 2012; 18(15): 1732-1744
URL: https://www.wjgnet.com/1007-9327/full/v18/i15/1732.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i15.1732