Overexpression of Dickkopf-3 induces apoptosis through mitochondrial pathway in human colon cancer

Figure 6 Overexpression of Dickkopf-3 inhibits downstream signaling and induces apoptosis in LoVo cells through mitochondrial pathway. A: Dickkopf-3 (Dkk-3) reduces cytoplasmic accumulation of β-catenin; B: Western blotting analysis of survivin, Bcl-2, Bax, cytochrome c, caspase-3 and caspase-9 protein after 48 h transfection with pEGFP-N1-Dkk-3-GFP plasmid in LoVo cells. Actin was used as a loading control. ^aP < 0.05 vs LoVo or pEGFP-N1 using Student’s t test.