A population-based cohort study of symptomatic gallstone disease in diabetic patients

Table 3 Overall age- and sex-specific incidence densities and relative hazards of gallstone disease (ICD-9: 574) in diabetic and control groups, 2000-2008, Taiwan, China

Variables1	Control group				Diabetic group				aHR2 (95% CI)24 in association with diabetic group
	No. of patients	No. of events	ID2 (per 1000 patient-years) (95% CI)23		No. of patients	No. of events	ID2 (per 1000 patient-years) (95% CI)23
Men
< 45	40 537	1467	4.25 (4.24-4.25)		40 537	2360	7.06 (7.06-7.07)		0.80 (0.66-0.96)4
45-64	141 899	9184	7.59 (7.58-7.59)		141 899	12 561	11.23 (11.22-11.23)		1.03 (0.96-1.09)4
> 64	113 127	10 241	12.31 (12.30-12.31)		113 129	12 224	16.40 (16.39-16.40)		1.20 (1.14-1.27)4
Total	295 563	20 892	8.75 (8.75-8.76)		295 566	27 145	12.35 (12.34-12.35)		1.12 (1.07-1.16)5
Women				Increased % vs males				Increased % vs males
< 45	29 080	1292	5.11 (5.11-5.12)	+ 20.8%	29 079	1898	7.69 (7.69-7.70)	+ 8.9%	0.75 (0.60-0.94)4
45-64	154 911	12 596	9.30 (9.29-9.30)	+ 22.5%	154 911	15 989	12.59 (12.58-12.59)	+ 12.1%	0.96 (0.90-1.02)4
> 64	135 317	13 336	12.61 (12.60-12.61)	+ 20.8%	135 318	15 685	16.81 (16.81-16.82)	+ 2.5%	1.13 (1.07-1.18)4
Total	319 308	27 224	10.21 (10.21-10.22)	+ 2.4%	319 310	33 572	13.70 (13.70-13.71)	+ 10.9%	1.05 (1.01-1.08)5
Overall	614 871	48 116	9.52 (9.52-9.53)		615 532	60 734	13.06 (13.06-13.07)		1.08 (1.05-1.10)6

¹Inconsistencies between the total population and the sums of populations for individual variables are due to missing information;

²ID: Incidence density; aHR: Adjusted hazard ratio;

³Based on poisson assumption;

⁴Based on Cox proportional hazard regression adjusted for all variables, except for age and sex;

⁵Based on Cox proportional hazard regression adjusted for all variables, except for sex;

⁶Based on Cox proportional hazards regression adjusted for age, sex, insurance premium, Charlson score, geographic area, urbanization status, and status of diabetes, hypertension, gout, hyperlipidemia, cystic fibrosis, cirrhosis, cholangitis, Caroli’s disease, Crohn's disease and hemolytic anemia.