Noninvasive Parameters and hepatic fibrosis scores in children with nonalcoholic fatty liver disease

Table 2 Comparison of hepatic fibrosis scoring systems between mild fibrosis and significant fibrosis regarding the hepatic histology of children with non-alcoholic fatty liver disease (mean ± SD)

Parameters and hepatic fibrosis scores	Total (n = 77)	Mild fibrosis(stage 0-1) (n = 51)	Significant fibrosis(stage 2-3) (n = 26)	P value
Invasive histopathologic NAFLD scores1
Steatosis (grade 0/1/2/3)	0/13/36/28	0/7/22/22	0/6/14/6	0.085
Inflammation (grade 0/1/2/3)	9/43/25/0	7/29/15/0	2/14/10/0	0.325
Ballooning (grade 0/1/2)	27/33/17	22/21/8	5/12/9	0.018
NAS	4.3 ± 1.4	4.18 ± 1.48	4.46 ± 1.14	0.470
Noninvasive hepatic fibrosis scoring systems
AST/ALT ratio	0.53 ± 0.22	0.52 ± 0.16	0.57 ± 0.31	0.802
AST/platelet ratio index	0.71 ± 0.49	0.67 ± 0.54	0.78 ± 0.38	0.032
PGA index	3.78 ± 1.80	3.85 ± 1.89	3.68 ± 1.70	0.710
Forns index	-0.94 ± 1.18	-1.06 ± 0.21	-0.69 ± 1.09	0.097
FIB4 score	0.27 ± 0.16	0.24 ± 0.12	0.31 ± 0.21	0.010
NAFLD fibrosis score	-4.95 ± 1.32	-5.07 ± 1.27	-4.73 ± 1.41	0.532
Pediatric NAFLD fibrosis index	7.67 ± 2.48	7.71 ± 2.79	7.61 ± 2.08	0.314

¹Histopathologic non-alcoholic fatty liver disease (NAFLD) scoring on liver biopsy specimens was based on the definition by Kleiner et al[13]. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; NAS: Non-alcoholic fatty liver disease activity score.