Second-line therapy for gemcitabine-pretreated advanced or metastatic pancreatic cancer

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Mar 28, 2012 (publication date) through Nov 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2012; 18(12): 1357-1364
Published online Mar 28, 2012. doi: 10.3748/wjg.v18.i12.1357

Table 4 Toxicity, dosage modifications and chemotherapy discontinuation n (%)

	Patients
Clinical toxicity grade 3-4
Nausea	3 (3.7)
Vomiting	5 (6.2)
Diarrhea	2 (2.4)
Stomatitis	1 (1.2)
Fever	6 (7.5)
Infection	6 (7.5)
Haematological toxicity grade 3-4
Anemia	2 (2.4)
Neutropenia	14 (17.1)
Thrombocytopenia	1 (1.2)
Dosage modifications	41 (51.3)
Type
Treatment suppression	7 (17.1)
Dose reduction	17 (41.5)
Delay of cycle	33 (80.5)
Discontinuation before evaluation	31 (41.3)
Progressive disease	23 (74.2)
Toxicity	3 (9.7)
Chemotherapy-related deaths	5 (16.1)

Citation: Altwegg R, Ychou M, Guillaumon V, Thezenas S, Senesse P, Flori N, Mazard T, Caillo L, Faure S, Samalin E, Assenat E. Second-line therapy for gemcitabine-pretreated advanced or metastatic pancreatic cancer. World J Gastroenterol 2012; 18(12): 1357-1364
URL: https://www.wjgnet.com/1007-9327/full/v18/i12/1357.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i12.1357