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Copyright ©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Mar 28, 2012; 18(12): 1286-1294
Published online Mar 28, 2012. doi: 10.3748/wjg.v18.i12.1286
Table 1 Mouse models of pancreatic adenocarcinoma
Genotype (reference)Time of expressionTime to tumor development (mo)Pancreatic cancer phenotypeSurvival (mo)
PDX-1-Cre; LSL-KrasG12D[39]E8.56PDAC; penetrant PanIN; age dependent increase severity; occasionally PDAC with long latency16
P48+/-Cre; LSL-KrasG12D[39]E9.58PDAC; penetrant PanIN; age dependent increase severity; occasionally PDAC with long latency16
PDX-1-Cre; LSL-KrasG12D; LSL-Trp53R172H/-[24]E8.52-3PDAC5-6
Accelerated PanIN; well differentiated PDCA
Mist1KrasG12D/+[25]E10.52Accelerated development of acinar-derived PanIN; mixed subtypes pancreatic cancer10.8
KPCBwt/wt[42]E8.52-3PDAC5.6
KPCBTr/wt[42]E8.53PDAC4.8
KPCBTr/Δ11[42]E8.51.5PDAC; mixed2.8
CKBwt/Δ11[41]E8.56PDAC12
CKBwt/wt[41]E8.56PDAC13.5
CPBΔ11/Δ11[41]E8.53-5PDAC; mixed10
Pdx1-Cre; KrasG12D Ink4a/Arfflox/flox[23]E8.52PDAC; accelerated development of PanIN; poorly differentiated PDAC2-3
Pdx1-Cre; KrasG12D Smad4flox/flox[55]E8.52-3IPMN; PDAC2-6
Ptf1acre/+; LSL-KrasG12D/+; Tgfbr2flox/flox[27]E9.51PDAC; accelerated PanIN; PDAC development2