Expression of HER2 and bradykinin B1 receptors in precursor lesions of gallbladder carcinoma

Figure 3 High magnification of gallbladder metaplastic epithelium showing immunoreactivity for HER2 (A) and bradykinin B₁ receptor receptor (B). Arrows show the limit between apical and basolateral cell membrane domains. C-G: Fluorescence in situ hybridization for HER2. Tissue sections were hybridized with a mixture of HER2-Texas Red and cen-17 labeled with fluorescein isothiocyanate. C: Normal gallbladder epithelium; D: Epithelium with intestinal metaplasia; E: Carcinoma in situ; F: Invasive carcinoma; G: Positive control corresponding to a breast cancer sample classified as HER2 + 3.