Polymorphisms of the TLR2 and TLR4 genes are associated with risk of gastric cancer in a Brazilian population

Table 5 Distribution of risk factors, genotypes of toll-like receptor 2 (-196 to -174 del) and toll-like receptor 4 (rs4986790 and rs4986791), and odds ratios for gastric cancer, chronic gastritis and control groups

Variables	F (GC/C) %	OR (95% CI)	P value	F (CG/C) %	OR (95% CI)	P value
Gender
Female	23/49.7	Reference	< 0.01	51.0/50.3	Reference	0.96
Male	77/50.3	2.70 (1.66-4.41)		49.0/49.7	0.99 (0.66 -1.48)
Age (yr)
< 61	40.9/56.0	Reference	0.30	52.8/43.5	(< 53 yr) Reference	0.03
≥ 61	59.1/44.0	1.26 (0.81-1.98)		47.2/56.5	(≥ 53 yr) 0.64 (0.43-0.95)
Smoking
Nonsmokers	30.5/34.3	Reference	0.13	44.8/34.3	Reference	0.01
Smokers	69.5/65.7	0.67(0.39-1.13)		55.2/65.7	0.57 (0.37-0.87)
Alcohol
Nondrinkers	46.6/74.3	Reference	< 0.01	68.2/74.3	Reference	0.06
Drinkers	53.4/25.7	2.93 (1.76-4.87)		31.8/25.7	1.54 (0.97-2.44)
TLR2
ins/ins	66.6/84.0	Reference	< 0.01	76.9/84.0	Reference	0.18
ins/del	33.4/16.0	2.64 (1.56-4.44)		23.1/16.0	1.39 (0.84 -2.28)
del/del
TLR4 +896A/G (rs4986790)
AA	88.5/95.5	Reference	< 0.01	89.9/95.5	Reference	0.04
AG	11.5/4.5	3.19 (1.34-7.61)		10.1/4.5	2.29 (1.02-5.13)
TLR4 +1196C/T (rs4986791)
CC	94.8/97.3	Reference	0.63	97.1/97.3	Reference	0.91
CT	5.2/2.7	1.33 (0.41-4.33)		2.9/2.7	0.93 (0.28-3.05)

F: Frequency of individual (%); OR: Odds ratio; GC: Gastric cancer; CG: Chronic gastritis; C: Control; TLR: Toll-like receptor.