Polymorphisms of the TLR2 and TLR4 genes are associated with risk of gastric cancer in a Brazilian population

Table 4 Combined effect of toll-like receptor 2 (-196 to -174 del) and toll-like receptor 4 (rs4986790 and rs4986791) polymorphisms on risk of gastric cancer and chronic gastritis

Risk genotype	Groups
	GC (n = 174)	C (n = 225)	OR (95% CI)P value	CG (n = 208)	C (n = 225)	OR (95% CI)P value	GC (n =174)	CG (n = 225)	OR (95% CI)P value
Neither	113	187	1.00 (reference)	160	187	1.00 (reference)	113	160	1.00 (reference)
TLR2 ins/del or del/ del/TLR4+896 AG	10	4	4.13 (1.26-13.50)	11	4	3.21 (1.00-10.29)	10	11	1.28 (0.52-3.13)
			0.02			0.06			0.64
TLR2 ins/del or del/ del/TLR4+1196 CT	4	1	6.61 (0.73-59.99)	1	1	1.16 (0.07-18.84)	4	1	5.66 (0.62-51.37)
			0.07			1.00			0.16
TLR4+896 AG/ +1196 CT	1	1	1.65 (0.10-26.73)	3	1	3.50 (0.36-34.05)	1	3	0.47 (0.04-4.59)
			1.00			0.34			0.64

C: Control group; OR: Odds ratio; GC: Gastric cancer; CG: Chronic gastritis; TLR: Toll-like receptor.