Polymorphisms of the TLR2 and TLR4 genes are associated with risk of gastric cancer in a Brazilian population

Table 2 Genotype and allele frequencies of toll-like receptor 2 (-196 to -174 del) and toll-like receptor 4 (rs4986790 and rs4986791) polymorphisms in gastric cancer, chronic gastritis and control groups

Genotypes/alleles	GC	C	CG
	n = 174 (%)	n = 225(%)	n = 208 (%)
TLR2 -196 to -174
ins/ins	116 (66.6)	189 (84.0)	160 (76.9)
del/ins	50 (28.7)	34 (15.1)	41 (19.7)
del/del	8 (4.7)	2 (0.9)	7 (3.4)
OR (95% CI)	2.62 (1.63-4.22) 1.57 (0.97-2.54)
P value	< 0.01 0.06
Alleles
ins	81.0	91.5	87.0
del	19.0	8.5	13.0
OR (95% CI)	2.53 (1.65-3.88) 1.65 (1.06-2.55)
P value	< 0.01 0.02
TLR4 +896A/G
(rs4986790)
AA	154 (88.5)	215 (95.5)	187 (89.9)
AG	20 (11.5)	10 (4.5)	21 (10.1)
GG	0	0	0
OR (95% CI)	2.79 (1.27-6.13) 2.41 (1.10-5.25)
P value	0.01 0.02
Alleles
A	94.0	97.0	95.0
G	6.0	3.0	5.0
OR (95% CI)	2.68 (1.23-5.81) 2.33 (1.08-5.02)
P value	0.01 0.02
TLR4 +1196C/T
(rs4986791)
CC	165 (94.8)	219 (97.3)	202 (97.1)
CT	9 (5.2)	6 (2.7)	6 (2.9)
TT	0	0	0
OR (95% CI)	1.99 (0.69-5.70) 1.08 (0.34-3.41)
P value	0.28 1.00
Alleles
C	98.0	99.0	98.0
T	2.0	1.0	2.0
OR (95% CI)	1.96 (0.69-5.57) 1.08 (0.34-3.38)
P value	0.29 1.00

OR: Odds ratio; GC: Gastric cancer; CG: Chronic gastritis; C: Control.