Expression of HER2 and bradykinin B1 receptors in precursor lesions of gallbladder carcinoma

Table 3 Expression of immunoreactive HER2, bradykinin B₁ receptor and Ki-67 in gallbladder adenomas and in adenocarcinoma and its putative precursor lesions (%)

Receptor/marker	Normal epithelium	Pyloric adenoma	Intestinal adenoma	Intestinal metaplasia	Carcinoma in situ	Invasive carcinoma
HER2	0/5	0/14	1/6 (17)	22/24 (91.7)a	9/10 (90)a	4/12 (33)
Bradykinin B1R	0/5	10/15 (67)a	6/6 (100)a	24/24 (100)a	10/10 (100)a	1/12 (8.3)
Ki-671	0.05 ± 0.005 (1.1)	0.05 ± 0.01 (5.1)	0.10 ± 0.01 (10.8)	0.36 ± 0.03b (36.7)	0.37 ± 0.05b (37.5)	0.42 ± 0.03b (42)

¹Proliferation index estimated as immunoreactivity to Ki-67 antigen.

^aP < 0.05,

^bP < 0.01 vs normal epithelium. B₁R: B₁ receptor.