Rebamipide suppresses diclofenac-induced intestinal permeability via mitochondrial protection in mice

Figure 5 Effects of rebamipide on diclofenac-induced liver mitochondrial swelling in mice. A: After adding the reaction buffer, the absorbance at 520 nm in the control mitochondria declined rapidly. The decrease was smaller in the presence of diclofenac compared with that in the control, demonstrating that liver mitochondrial dysfunction was induced by diclofenac administration. This reduction in absorbance was significantly increased in the presence of rebamipide, indicating that rebamipide improved impaired mitochondrial function; B: After adding 0.3 mmol/L CaC1₂ reaction buffer, the absorbance at 520 nm in the control mitochondria declined rapidly, suggesting significant swelling of mitochondria. The decrease was smaller in the presence of diclofenac compared with that in the control, demonstrating that liver mitochondrial dysfunction was induced by diclofenac administration. This reduction was significantly increased in the presence of rebamipide, indicating that rebamipide improved impaired mitochondrial function.