Rebamipide suppresses diclofenac-induced intestinal permeability via mitochondrial protection in mice

Figure 4 Effects of rebamipide on diclofenac-induced liver mitochondrial membrane potential. In the control group, the fluorescence intensity was reduced within 30 s, and then began to rise and reached a steady state within 90 s. The fluorescence intensity reduction in the diclofenac group was smaller than that in the control group, indicating that the liver mitochondrial membrane potential was decreased by diclofenac administration. The reduction in the fluorescence intensity in the rebamipide group was greater than that in the diclofenac group indicating that rebamipide improved the impairment in mitochondrial function induced by diclofenac.