Recurrence and rejection in liver transplantation for primary sclerosing cholangitis

Table 3 Studies containing data on the incidence of acute cellular rejection after liver transplantation for primary sclerosing cholangitis

Ref.	Yr	No. ofPSC patients	Median follow-up(range) in months	ACRn (%)	Diagnostic criteria for rejection	Immunosuppression
Klintmalm et al[179]	1988	9	ND (ND)	4 (44)	Biopsy	CyA, CS and azathioprine
McEntee et al[180]	1991	44	ND (ND)	44 (100)	ND	ND
Shaked et al[181]	1992	36	ND (ND)	6 (17)	Biopsy	CyA/Tac, CS and azathioprine
Miki et al[3]	1994	55	ND (ND)	37 (67)	Biopsy	CyA/Tac, CS and azathioprine
Narumi et al[30]	1995	33	37.8 (6-73)	19(57)	Biopsy	ATG for 3-5 d, CS, azathioprine and delayed CyA
Farges et al[131]	1996	23	Minimal follow-up 18 mo	12 (52)	Biopsy	CyA/Tac, CS and azathioprine
Jeyarajah et al[70]	1998	115	Minimal follow-up 12 mo	45 (39)	Biopsy	CyA/Tac, CS and azathioprine
Wiesner et al[130]	1998	126	34	58 (46)	Biopsy	CyA/Tac, CS and azathioprine (1 group received induction with ATG)
Graziadei et al[10]	1999	150	55 (10-138)	103 (69.7)	Biopsy	CyA/Tac, CS and azathioprine
Bathgate et al[182]	2000	16	ND (ND)	10 (63)	Biopsy	ND
Brandsaeter et al[75]	2005	49	77 (17-182)	35 (71)	Biopsy	CyA/Tac, CS and azathioprine/ MMF

PSC: Primary sclerosing cholangitis; ACR: Acute cellular rejection; ND: Not determined; MMF: Mycophenolate mofetil; ATG: Anti-T-lymphocyte Globulin; CyA: Cyclosporine A; Tac: Tacrolimus; CS: Corticosteroid.