Metastasis-associated protein 1 induces VEGF-C and facilitates lymphangiogenesis in colorectal cancer

Figure 4 Metastasis-associated protein 1 regulates the expression of vascular endothelial growth factor-C in colorectal cancer cell lines. Western blotting (left panel) and real-time PCR (right panel) showing different expressions of metastasis-associated protein 1 (MTA1) and VEGF-C in HCT116 and LoVo cell lines (A), increased VEGF-C expression in LoVo cells due to overexpression of MTA1 (B), and decreased VEGF-C expression in HCT116 cells due to knocked down MTA1 (C). 1 and 2 indicate two different si-MTA1 oligonucleotide as showed in "Materials and Methods". All data represent three independent experiments ± SE, with n = 3 and ^bP < 0.01. VEGF-C: Vascular endothelial growth factor-C.