Effects of prostaglandin F2α on small intestinal interstitial cells of Cajal

Figure 6 The effects of chelerythrine or calphostin C on the prostaglandin F_2α-induced response in pacemaker currents in cultured interstitial cells of Cajal from mouse small intestine. A and C: Pacemaker currents of interstitial cells of Cajal exposed to prostaglandin F_2α (PGF_2α) (10 μmol/L) in the presence of chelerythrine (1 μmol/L) or calphostin C (1 μmol/L). Under these conditions, the PGF_2α caused tonic inward currents. The dotted lines indicate the zero current levels. Responses to the PGF_2α in the presence of chelerythrine or calphostin C are summarized in B and D. Vertical solid line scales denote amplitude of pacemaker current and horizontal solid line scales denote duration of recording (s) pacemaker current. The bars represent mean ± SE. No significant difference from the untreated control.