Effects of prostaglandin F2α on small intestinal interstitial cells of Cajal

Figure 5 The effects of U-73122 on the prostaglandin F_2α-induced response in pacemaker currents of cultured interstitial cells of Cajal from mouse small intestine. A: U-73122 (5 μmol/L) abolished the generation of pacemaker currents. U-73122 also blocked the Prostaglandin F_2α (PGF_2α) (10 μmol/L)-induced tonic inward currents. The dotted lines indicate the zero current levels. Responses to the PGF_2α are summarized in B. Vertical solid line scales denote amplitude of pacemaker current and horizontal solid line scales denote duration of recording (s) pacemaker current. The bars represent mean ± SE. The effect of U-73122 on PGF_2α-induced pacemaker currents was significantly different from the PGF_2α-induced pacemaker currents in the absence of U-73122 (^bP < 0.01).