Effects of prostaglandin F2α on small intestinal interstitial cells of Cajal

Figure 3 The effects of 5’-[-thio]diphosphate trilithium salt on response to prostaglandin F_2α-induced pacemaker currents from interstitial cells of Cajal from mouse small intestine. A: Pacemaker currents from interstitial cells of Cajal exposed to prostaglandin F_2α (PGF_2α) (10 μmol/L) in the presence of 5’-[-thio]diphosphate trilithium salt (GDP-β-S) (1 mmol/L) in the pipette. The tonic inward currents with suppressed amplitude and frequency induced by PGF_2α remained unchanged during internally applied GDP-β-S (1 mmol/L). The dotted lines indicate the zero current levels. The effects of PGF_2α in the presence of GDP-β-S are summarized in B. Vertical solid line scales denote amplitude of pacemaker current and horizontal solid line scales denote duration of recording (s) pacemaker currents. Bars represent mean ± SE. The effects of GDP-β-S on PGF_2α-induced pacemaker currents were not significantly different from the PGF_2α-induced pacemaker currents in the absence of GDP-β-S.