Effects of prostaglandin F2α on small intestinal interstitial cells of Cajal

Figure 2 The effects of flufenamic acid or niflumic acid on prostaglandin F_2α-induced responses in pacemaker currents in cultured interstitial cells of Cajal from mouse small intestine. A: Application of flufenamic acid (10 μmol/L) abolished the generation of pacemaker currents. Under these conditions, the prostaglandin F_2α (PGF_2α) (10 μmol/L) did not produce tonic inward currents; C: Niflumic acid (10 μmol/L) also abolished the generation of pacemaker currents. However, niflumic acid did not block the PGF_2α (10 μmol/L)-induced tonic inward currents. The dotted lines indicate zero current levels. Responses to the PGF_2α in the presence of flufenamic acid or niflumic acid are summarized in B and D. Vertical solid line scales denote amplitude of pacemaker current and horizontal solid line scales denote duration of recording (s) pacemaker currents. The bars represent mean ± SE. ^bP < 0.01 vs the untreated control.