Effects of prostaglandin F2α on small intestinal interstitial cells of Cajal

Figure 1 The effects of Prostaglandin F_2α on pacemaker potentials and pacemaker currents recorded in cultured interstitial cells of Cajal from mouse small intestine. A: Pacemaker potentials of interstitial cells of Cajal (ICC) exposed to Prostaglandin F_2α (PGF_2α) (10 μmol/L) in the current-clamping mode (I = 0). Vertical solid line scales denote amplitude of pacemaker potential and horizontal solid line scales denote duration of recording (s) pacemaker potentials; B-D: Pacemaker currents of ICC recorded at a holding potential of -70 mV exposed to various concentrations of PGF_2α (1, 5, and 10 μmol/L). The dotted lines indicate zero current levels. Vertical solid line scales denote amplitude of pacemaker current and horizontal solid line scales denote duration of recording (s) pacemaker currents. The responses to PGF_2α are summarized in E-G. The bars represent mean ± SE. ^bP < 0.01 vs the untreated control.